Thermo Fisher Scientific CD45 Polyclonal Antibody, FITC
FITC로 결합된 Thermo Fisher Scientific CD45 폴리클로날 항체로 인간 및 비인간 영장류에 반응합니다. Western blot, ELISA, IP 등 다양한 응용에 적합하며, 고순도 친화 크로마토그래피 정제 제품입니다. -20°C에서 어두운 곳에 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1100–1150 on human Receptor-type tyrosine-protein phosphatase C |
| Conjugate | FITC (Fluorescein Isothiocyanate) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. It is absent in non-hematopoietic cells and tissues. CD45 glycoprotein is essential for lymphocyte development and antigen signaling, regulating Src-family kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing transmembrane and cytoplasmic regions. CD45RA, a specific isoform, shows restricted expression among lymphoid subtypes. CD45 plays a key role in T- and B-cell receptor signaling, cytokine receptor regulation via JAK kinases, and integrin-mediated signal transduction, influencing apoptosis and immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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