Thermo Fisher Scientific CD4 Polyclonal Antibody
Western blot, IHC, ELISA, IP 등 다양한 응용에 적합한 CD4 폴리클로날 항체. Human, Mouse, Rat 등 반응성. Rabbit IgG로 생산, Affinity chromatography로 정제. -20°C 보관, 연구용 전용.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to Human CD4 aa 437–458 (C terminal). The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using a hetero-bifunctional cross linker for immunogen preparation. Sequence: RLLSEKKTCQCPHRFQKTCSPI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CD4 antigen is involved in the recognition of MHC class II molecules and serves as a co-receptor for HIV. CD4 is primarily expressed in T helper lymphocytes but may also be found in monocytes, macrophages, and dendritic cells.
At the tissue level, CD4 expression can be detected in thymus, lymph nodes, tonsils, spleen, and specific regions of the brain and gut.
It functions to initiate or augment early T-cell activation through association with the T-cell receptor complex and protein tyrosine kinase Lck.
CD4 may also act as a mediator of neuronal damage in infectious and immune-mediated CNS diseases.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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