Thermo Fisher Scientific HMGN3 Polyclonal Antibody
Human HMGN3 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 실험에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 인간 반응성, 4°C 보관, 연구용 전용.
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Thermo Fisher Scientific HMGN3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 30 and 60 of human high mobility group nucleosomal binding domain 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Predicted to react with Orangutan based on 100% sequence identity
Target Information
HMGN3 binds to nucleosomes, regulating chromatin structure and processes such as transcription, DNA replication, and DNA repair. It influences insulin and glucagon levels and modulates pancreatic gene expression related to insulin secretion. It regulates the glucose transporter SLC2A2 by binding to its promoter region and recruiting transcription factors including PDX1. It also regulates SLC6A9, a glycine transporter affecting synaptic glycine concentration in the CNS, and may play roles in ocular development and astrocyte function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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