Thermo Fisher Scientific Girdin Monoclonal Antibody (M012)
Girdin 단백질을 인식하는 Mouse Monoclonal Antibody (Clone M012). Western blot, IHC, ICC/IF, IP에 사용 가능. 인간 시료 반응성. 액상 형태로 제공되며, Protein G로 정제됨. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:250 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M012 |
| Immunogen | Clone (M012) was generated from a recombinant protein that included amino acid residues within the C-terminal region of human Girdin. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | ~0.25 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942700 |
Product Specific Information
Clone M012 mouse monoclonal antibody detects a 250 kDa protein on SDS-PAGE immunoblots of human A431 cells and human brain tissue.
This antibody is suitable for use in immunoprecipitation, immunohistochemistry, and immunocytochemistry.
Target Information
Girdin is a Galpha-interacting protein that enhances activation of the protein kinase Akt, remodels the actin cytoskeleton, and is involved in regulating cell migration and cancer metastasis.
It interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is involved in migration, positioning, and differentiation of dentate granule cells (DGCs) during development.
Depletion of Girdin or blocking the Girdin–DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and abnormal migration of DGCs, suggesting Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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