Thermo Fisher Scientific Phospho-c-Met (Tyr1365) Polyclonal Antibody
Phospho-c-Met (Tyr1365) 폴리클로날 항체로 인간, 마우스, 랫트 반응성. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. KLH 결합 인산화 펩타이드 항원 유래, Protein A 정제. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human C-Met around the phosphorylation site of Tyr1365 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET plays roles in embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation) and in adults (wound healing, organ regeneration, tissue remodeling).
Aberrant MET signaling is associated with cancers including gastric, renal, and breast, making it a target for cancer therapeutics and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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