Thermo Fisher Scientific HMCES Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 93%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 79%, Rabbit: 100%, Rat: 93%

Target Information

Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross-link is degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a "suicide" enzyme that protects abasic sites from translesion synthesis polymerases and endonucleases that are error-prone. Has preference for ssDNA, but can also accommodate dsDNA with 3′ or 5′ overhangs and dsDNA-ssDNA junctions. Also involved in class switch recombination (CSR) in B-cells independently of DNA-protein cross-link formation, promoting DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway. Acts as a protease mediating autocatalytic processing of its N-terminal methionine to expose the catalytic cysteine.
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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