Thermo Fisher Scientific ADAM17 Polyclonal Antibody
ADAM17 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용 가능. 인간 및 비인간 영장류 반응성. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공.
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Thermo Fisher Scientific ADAM17 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | View publication |
| Immunoprecipitation (IP) | 1:100 | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids surrounding Val200 of human TACE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 90 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980438 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.
ADAM17 is responsible for the proteolytic release of soluble JAM3 from endothelial cell surfaces and several other cell-surface proteins, including:
- p75 TNF-receptor
- Interleukin receptor type II
- p55 TNF-receptor
- Transforming growth factor-alpha
- L-selectin
- Growth hormone receptor
- MUC1
- Amyloid precursor protein
It acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Mutations in the gene can result in inflammatory skin and bowel disease, neonatal type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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