Thermo Fisher Scientific SETD8 Monoclonal Antibody (OTI2B3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

SETD8 is a histone methyltransferase that specifically monomethylates Lys-20 of histone H4.
H4 Lys-20 monomethylation is enriched during mitosis and serves as a specific marker for epigenetic transcriptional repression.
SETD8 primarily functions in euchromatin regions, playing a central role in silencing euchromatic genes.
It is required for cell proliferation by maintaining proper higher-order DNA structure during mitosis and is involved in chromosome condensation and cytokinesis.
Nucleosomes are preferred substrates compared to free histones.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.