Thermo Fisher Scientific alpha-2-Macroglobulin Polyclonal Antibody
Human α2-Macroglobulin을 인식하는 Goat Polyclonal Antibody로, WB, IHC, ELISA, IP에 적합. 비결합형(Unconjugated) 형태이며, Lyophilized 상태로 제공. Alzheimer 연구 등에서 단백질 결합 및 방어 기전 분석에 활용 가능.
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Thermo Fisher Scientific alpha-2-Macroglobulin Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,500 |
| ELISA | 1:20,000–1:100,000 |
| Immunoprecipitation (IP) | 1:2,000–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | a2-Macroglobulin [Human Plasma] |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 82 mg/mL |
| Storage Buffer | 0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at 4°C prior to restoration.
- For extended storage, aliquot contents and freeze at -20°C or below.
- Avoid repeated freeze/thaw cycles.
- Centrifuge if not clear after standing at room temperature.
- Stable for several weeks at 4°C as undiluted liquid.
- Dilute only prior to immediate use.
- Immunoelectrophoresis shows a single precipitin arc against anti-goat serum and purified human plasma a2-Macroglobulin.
- Cross-reactivity with a2-Macroglobulin from other sources is unknown.
Target Information
Alpha 2-Macroglobulin (α2M) is an approximately 720 kDa homotetrameric glycoprotein composed of four identical 180 kDa subunits.
It shares structural similarity with other alpha-macroglobulins such as complement components C3, C4, and pregnancy zone protein (PZP).
α2M acts as a panprotease inhibitor, binding a wide range of proteinases and serving as a humoral defense barrier against foreign peptides.
In Alzheimer’s disease (AD) brains, α2M is localized to diffuse amyloid plaques, suggesting a role in AD pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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