Thermo Fisher Scientific CBX8 Monoclonal Antibody (OTI5F3), TrueMAB
Human CBX8 단백질(아미노산 1-260)에 특이적인 Mouse IgG1 단클론 항체로 Western Blot과 IHC(P) 적용 가능. Lyophilized 형태로 제공되며, PBS buffer(8% trehalose) 보존. 연구용으로 사용되며, PRC1 복합체 관련 유전자 발현 조절 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–260 of human CBX8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
CBX8 is a component of the Polycomb group (PcG) multiprotein PRC1-like complex, which maintains transcriptional repression of many genes, including Hox genes, during development.
The PRC1 complex acts through chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A at Lys-119, resulting in heritable changes in chromatin expressibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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