Thermo Fisher Scientific CD40 Monoclonal Antibody (FGK45.5)
마우스 CD40 항원을 인식하는 Rat IgG2a 단클론 항체로, ICC/IF, Flow Cytometry, Functional Assay에 적합합니다. Protein A/G로 정제된 액상 형태이며, 4°C에서 보관합니다. 인간에는 반응하지 않으며 연구용으로만 사용됩니다.
- 카탈로그번호
- RTM1-2005-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD40 Monoclonal Antibody (FGK45.5)
Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg / 10⁶ cells |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FGK45.5 |
| Immunogen | Purified recombinant Mouse CD40 fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Does not react with Human.
Target Information
The CD40 antigen is a single-chain glycoprotein belonging to the tumor necrosis factor/nerve growth factor superfamily. It shows significant homology to the Hodgkin’s disease-associated antigen CD30. CD40 is expressed on all B cells except plasma cells and is also found on some epithelial cells, carcinomas, and lymphoid dendritic cells. It plays essential roles in immune and inflammatory responses, including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
The AT-hook transcription factor AKNA regulates CD40 expression, facilitating homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and mediates signal transduction. The CD40-CD40L interaction is necessary for amyloid-beta-induced microglial activation, an early event in Alzheimer’s disease pathogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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