Thermo Fisher Scientific IL-10R1 (Interleukin-10 Receptor 1) (CD210) Monoclonal Antibody (1B1.3a)
Mouse IL-10R1 (CD210) 단백질을 인식하는 Rat monoclonal antibody로, ICC/IF, Flow Cytometry, Neutralization에 사용 가능. Human에는 반응하지 않으며, Protein A/G로 정제된 1 mg/mL 액상 형태. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10^6 cells |
| Neutralization (Neu) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B1.3a |
| Immunogen | Purified recombinant extracellular region of Mouse IL10RA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Human
Target Information
The protein encoded by this gene is a receptor for interleukin 10. It is structurally related to interferon receptors and mediates the immunosuppressive signal of interleukin 10, thereby inhibiting synthesis of proinflammatory cytokines.
This receptor promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
Two transcript variants (one protein-coding, one non-coding) have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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