Thermo Fisher Scientific PSMD2 Polyclonal Antibody

Thermo Fisher Scientific PSMD2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, and Orangutan

Target Information

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of two complexes: a 20S core and a 19S regulator.

• The 20S core contains four rings of 28 non-identical subunits (two rings of seven alpha and two rings of seven beta subunits).
• The 19S regulator consists of a base (six ATPase and two non-ATPase subunits) and a lid (up to ten non-ATPase subunits).
  Proteasomes are abundant in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
  The immunoproteasome plays an essential role in processing class I MHC peptides.
  This gene encodes one of the non-ATPase subunits of the 19S regulator lid and may also participate in the TNF signaling pathway via interaction with the TNF type 1 receptor.
  A pseudogene has been identified on chromosome 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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