Thermo Fisher Scientific NMNAT3 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NMNAT3 (NP_835471.1, 1 a.a. approximately 215 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NMNAT3,uniProtId:Q96T66-1,ncbiNodeId:9606,antigenRange:1-252,antigenLength:252,antigenImageFileName:H00349565-B01P_NMNAT3_Q96T66-1_House_mouse.svg,antigenImageFileNamePDP:H00349565-B01P_NMNAT3_Q96T66-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MYQVIQGIIS PVNDTYGKKD LAASHHRVAM ARLALQTSDW IRVDPWESEQ AQWMETVKVL RHHHSKLLRS PPQMEGPDHG KALFSTPAAV PELKLLCGAD VLKTFQTPNL WKDAHIQEIV EKFGLVCVGR VGHDPKGYIA ESPILRMHQH NIHLAKEPVQ NEISATYIRR ALGQGQSVKY LIPDAVITYI KDHGLYTKGS TWKGKSTQST EGKTS

Target Information

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.