Thermo Fisher Scientific p23 Polyclonal Antibody
Thermo Fisher Scientific의 p23 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 WB, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, 단백질 발현 및 스테로이드 수용체 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length human p23 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.31 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547023 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain, RK3E cells
- Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (86%), Chicken (96%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%)
- Store as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with various proteins in both stable and transient fashions. These include heat shock proteins (HSP70, HSP90), immunophilins (FKBP52, FKBP54, CyP-40), and other proteins such as p23, p60, and p48.
p23, along with HSP70, HSP90, and p60, forms part of a transient intermediate complex with the progesterone receptor (PR). The cloned human p23 protein consists of 160 amino acids, highly conserved among species, and functions as an acidic phosphoprotein with multiple phosphorylation sites. It interacts with HSP90 and is essential for the binding of HSP90 and CyP-40 to PR, suggesting a critical role in PR function.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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