Thermo Fisher Scientific SKP2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A–Cdk2 complex.
Skp2 is essential for the G1–S transition in both transformed cells and diploid fibroblasts. It is required for the ubiquitination and degradation of p27 in mammalian cells.
In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, it is widely expressed, including colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers.
Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.