Thermo Fisher Scientific KCNMA1 Polyclonal Antibody
Thermo Fisher Scientific KCNMA1 Polyclonal Antibody는 인간 KCNMA1 단백질의 450-500번 영역을 면역원으로 한 토끼 IgG 항체입니다. Western blot과 IP에 적합하며, 다양한 종에 교차 반응성을 보입니다. 액상 형태로 1 mg/mL 농도, 4°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,500
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 450 and 500 of human Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Alpha Member 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, X. laevis, Chicken, Bovine, Dog, Rabbit, Pig, and Monkey
Target Information
Potassium channels are ubiquitously expressed proteins serving numerous functions in excitable and non-excitable cells. The large conductance, calcium-activated potassium channel (Maxi K+) is unique in that its activation is controlled by both intracellular calcium increase and membrane depolarization.
The Maxi K+ alpha homotetramer contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is present in a 1:1 ratio, reducing the calcium concentration required to open the channel pore by 5–10 fold.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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