Thermo Fisher Scientific CD28 Recombinant Mouse Monoclonal Antibody (D665)
CD28 단백질을 인식하는 Mouse 재조합 단클론 항체(D665)로, T 세포 활성화 및 면역학 연구에 적합합니다. IHC, Flow Cytometry, Functional Assay 등 다양한 응용에 사용 가능하며, HEK293 발현 시스템에서 생산된 IgG1, kappa 형식의 항체입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Functional Assay (Functional) | Assay-dependent |
| T-Cell Activation (TCA) | Assay-dependent |
| Surface Plasmon Resonance (SPR) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | D665 |
| Immunogen | The original D665 antibody was generated by immunizing mice alternately with A20 cells expressing mCD28 (i.p.) and with recombinant mCD28Ig (s.c.). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074315 |
Product Specific Information
- Specificity: This antibody binds to the laterally exposed CD loop of CD28 and induces T cell proliferation without TCR ligation.
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein.
It is a cell adhesion molecule of the immunoglobulin superfamily, constitutively expressed on most peripheral blood T lymphocytes.
CD28 acts as a critical T cell costimulatory receptor by binding CD80 and CD86 on antigen-presenting cells, providing the essential second activation signal.
Additionally, CD28 prevents T cells from entering an anergic or apoptotic state.
In murine lymphoid organs and blood, all CD4+ and CD8+ T cells express CD28, with varying expression levels during thymocyte maturation.
Diseases associated with CD28 dysfunction include mycosis fungoides and Sezary’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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