Thermo Fisher Scientific CNGB3 Polyclonal Antibody
Rabbit 유래 CNGB3 폴리클로날 항체로 시각 신호전달 관련 단백질 연구에 적합. 비결합형 액상 형태이며 0.2 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CNGB3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664892 |
Product Specific Information
Immunogen sequence:
NPDPQNAAEPT GTVPEQKEMD PGKEGPNSPQ NKPPAAPVIN EYADAQLHNL VKRMRQRTAL YKKKLVEGDL SSPEASPQTA KPTAVPPVKE SDDKPTEHYY RLLWFKVKKM PLTEYLKRIK LPNS
Highest antigen sequence identity to the following orthologs:
- Mouse: 47%
- Rat: 46%
Target Information
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. It induces flickering channel gating, weakens outward rectification in the presence of extracellular calcium, increases sensitivity for L-cis diltiazem, and enhances cAMP efficiency of the channel when coexpressed with CNGA3.
Essential for the generation of light-evoked electrical responses in red-, green-, and blue-sensitive cones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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