Thermo Fisher Scientific MDM2 Monoclonal Antibody (2A10)
인간 MDM2 단백질을 인식하는 Mouse IgG2a 단일클론 항체. 파라핀 조직 면역조직화학(IHC-P)에 적합하며, 단백질 A로 정제된 액상 형태. p53 안정성 조절 및 종양 억제 연구에 활용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC-P)
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A10 |
| Immunogen | Synthetic peptide SRPSTSSRRAISE derived from human MDM2 (amino acids 154–167) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C (short term); for long-term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human breast carcinoma
- Cellular Location: Nucleus
Target Information
MDM2 is a ubiquitin ligase for p53 and plays a central role in regulating the stability of p53. It is located on chromosome 12q. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 enhances its interaction with p300, promoting MDM2-mediated ubiquitination and degradation of p53. Phosphorylation also inhibits binding to p19ARF, further increasing p53 degradation. Overexpression of MDM2 can inactivate p53 and reduce its tumor suppressor function.
MDM2 is involved in apoptosis and cell cycle regulation and is overexpressed in various human malignancies, including soft tissue carcinomas and breast cancer. It also interacts with proteins such as retinoblastoma 1 and ribosomal protein L5. More than 40 alternatively spliced transcript variants of MDM2 have been identified in both tumor and normal tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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