Thermo Fisher Scientific WDR59 Polyclonal Antibody
WDR59 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 사용 가능. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며 연구용으로 적합.
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- PA559420
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- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human WDR59. Recombinant protein control fragment (Product #RP-98626) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2649595 |
Product Specific Information
Immunogen sequence:
TSSQDNSVKF WDYRQPRKYL NILPCQVPVW KARYTPFSNG LVTVMVPQLR RENSLLLWNV FDLNTPVHTF VGHDDVVLEF QWRKQKEGSK D
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 99%
Target Information
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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