Thermo Fisher Scientific GPR125 Polyclonal Antibody

Thermo Fisher Scientific GPR125 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. Purity is >95% (by SDS-PAGE).

Target Information

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors or 7TM receptors, form a superfamily of proteins involved in diverse stimulus-response pathways. They translate extracellular signals into intracellular responses through G protein activation and respond to various signaling molecules such as hormones and neurotransmitters.

GPR125 (G protein-coupled receptor 125), also known as PGR21 or TEM5L, is a 1,321 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and the LN-TM7 subfamily. It is considered a novel orphan adhesion-type G-protein-coupled receptor with five leucine-rich repeats (LRR), an immunoglobulin (Ig) domain, and a GPS domain. GPR125 may play a functional role in choroidal and hippocampal responses to brain injury and is suggested as a marker for spermatogonial stem cells. Four isoforms of GPR125 exist due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.