Thermo Fisher Scientific DCT Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human DCT (NP_0019132) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DCT,uniProtId:P40126-1,ncbiNodeId:9606,antigenRange:50-350,antigenLength:519,antigenImageFileName:PA5-90899_DCT_P40126-1_Rabbit.svg,antigenImageFileNamePDP:PA5-90899_DCT_P40126-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.66 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806280

Product Specific Information

Immunogen sequence: NVCGSQQGRG QCTEVRADTR PWSGPYILRN QDDRELWPRK FFHRTCKCTG NFAGYNCGDC KFGWTGPNCE RKKPPVIRQN IHSLSPQERE QFLGALDLAK KRVHPDYVIT TQHWLGLLGP NGTQPQFANC SVYDFFVWLH YYSVRDTLLG PGRPYRAIDF SHQGPAFVTW HRYHLLCLER DLQRLIGNES FALPYWNFAT GRNECDVCTD QLFGAARPDD PTLISRNSRF SSWETVCDSL DDYNHLVTLC NGTYEGLLRR NQMGRNSMKL PTLKDIRDCL SLQKFDNPPF FQNSTFSFRN A; Positive Samples: MCF7, A-375, HeLa, Mouse brain; Cellular Location: Melanosome membrane, Single-pass type I membrane protein

Target Information

The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteinerich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exist as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.