Applied Biosystems™

Axiom™ Transplant Genotyping Array

Axiom™ Transplant Genotyping Array, one of the Axiom™ Biobank Genotyping Arrays, is designed for high-powered, genome-wide genotyping of large sample자세히 알아보기

Axiom™ Transplant Genotyping Array, one of the Axiom™ Biobank Genotyping Arrays, is designed for high-powered, genome-wide genotyping of large sample collections such as those screened at biobanks, genome centers, and core labs.

Axiom Transplant Genotyping Array was designed by and for thought leaders in the human genetics community for high-throughput, high-value genotyping of large sample cohorts to explore the genetics of complex diseases and translational research with a single comprehensive low-cost solution.

GWAS

•Intelligent marker selection enables imputation of millions of additional SNPs
•The genomic content module of each array is optimized for specific populations and is customizable to any 1000 Genomes population study by adding additional markers of your choosing

Transplant

•Content specific for transplantation research including functional variants, loss-of-function markers, and copy number
•Immune function, including content covering the major histocompatibility complex (MHC), human leukocyte antigen (HLA), and killer-cell immunoglobulin-like receptors (KIR)

Pharmacogenomic markers

•Markers were selected to represent phases of absorption, distribution, metabolism, and excretion (ADME)

Inflammation and HLA

•Contains markers with evidence for association with autoimmune and inflammation
•Covers variants in genes in the HLA and KIR regions known to be important in immune response

Exome

•Rare, non-synonymous coding SNPs and indels in protein coding regions of the genome
•A majority of variants are rare with minor allele frequency (MAF) <1%
•Newly discovered loss-of-function content
•SNPs and indels identified from a sequencing initiative of 26,000 individuals
•Known disease-causing mutations

eQTLs

•Markers that have known associations to RNA expression traits
•Captures unique eQTLs contained in the NCBI Genotype-Tissue Expression (GTEx) eQTL database, GEUVIDAS project, and several other discovery projects

Human disease

•Alzheimer`s disease, including coverage of ApoE
•Blood phenotypes
•Cancer common variants
•Cardiometabolic

Choose your content

•Order the pre-designed array and customize it with markers of your choice
•Custom markers may be de novo or selected from the Axiom™ Genomic Database of genotype-tested markers

Please note: Reagent kits do not include plastic consumables required to run the assay on the Beckman Biomek™ FXP Target Prep Express System. For a list of required Beckman consumables, please see the Axiom™ 2.0 Automated Assay User Guide below.

사양

어레이Genotyping

어레이 수96 arrays

형식96-array Plate

종Human

용도(애플리케이션)Microarray Analysis

수량1 plate

Unit SizeEach