Thermo Fisher Scientific MMP2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
YGASPDIDLG TGPTPTLGPV TPEICKQDIV FDGIAQIRGE IFFFKDRFIW RTVTPRDKPM GPLLVATFWP ELPEKIDAVY EAPQEEKAVF FAGNEYWIYS ASTLERGYPK PLTSLGLPPD VQRVDAAFNW S

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a conserved activation mechanism and are inhibited by tissue inhibitors of metalloproteinases (TIMPs). MMP2 is synthesized as a 631-amino-acid proenzyme, activated by cleavage of the first 80 amino acids, and includes propeptide, catalytic, and hemopexin domains.

MMPs degrade extracellular matrix components such as collagens, fibronectin, laminin, and glycoproteins. They typically consist of a signal peptide, a propeptide, and a catalytic domain containing a zinc-binding site. Functionally, MMP2 is involved in tissue remodeling. Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.