Thermo Fisher Scientific HPV16 E1/E4 (Human Papilloma Virus 16) Monoclonal Antibody (HPV16 E1/E4)
HPV16 E1/E4 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체. 면역조직화학(IHC) 분석에 적합하며, 바이러스성 단백질 검출용으로 사용. 비결합형 액상 형태로 제공되며, 4°C에서 보관.
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Thermo Fisher Scientific HPV16 E1/E4 Monoclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HPV16 E1/E4 |
| Immunogen | Recombinant human HPV16 E1/E4 fragment (aa 36–41) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a high-risk sexually transmitted type that can lead to cervical, anal, vulvar, head, neck, and penile cancers.
HPV16 E1/E4 protein is abundantly expressed in cells supporting viral DNA amplification but is lost during malignant progression. It induces G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes.
HPV16 E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase, enhancing its ability to prevent mitotic entry. Additionally, it associates with keratin intermediate filaments, causing the network to collapse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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