Thermo Fisher Scientific TRAF7 Polyclonal Antibody
TRAF7 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC/IF, ELISA 등 다양한 면역분석에 활용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TRAF7, amino acids 451–550 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TRAFs are signal transducers for members of the TNFR superfamily and are critically involved in activation of MAP3K family members related to NF-kappaB and JNK activation and apoptosis.
TRAF7, a novel 670 amino acid protein, is a human homolog of mouse Traf7 and consists of an N-terminal RING finger domain, a central TRAF domain, a coiled-coil motif, and seven WD40 repeats at the C-terminus.
It exhibits E3-ubiquitin ligase activity for self-ubiquitination and specifically interacts with MEKK3 to mediate MEKK3-induced AP1 and CHOP activation. TRAF7 induces apoptosis through caspase-independent pathways and is involved in sumoylation and negative regulation of c-Myb, thereby influencing proliferation and differentiation of hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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