Thermo Fisher Scientific GRIK1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GRIK1 (GLUR5), suitable for WB and IHC. Lyophilized form for research use only. High specificity for excitatory amino acid receptor 3, involved in neuronal signaling studies. Stable storage at -20°C with optio...
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous (PubMed) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from 1st extracellular domain of human GRIK1 (GLUR5, Excitatory amino acid receptor 3) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term; for long term, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: GRIK1.
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in various normal neurophysiological processes.
GRIK1 (also known as glutamate receptor 5) belongs to the kainate family of glutamate receptors, functioning as ligand-activated ion channels composed of four subunits.
GRIK1 is expressed in GABAergic interneurons of the hippocampus and participates in forming kainate receptor subtypes with GRIK2 and KA2.
Stimulation of GRIK1 leads to intracellular calcium release and activation of protein kinase C.
Excessive activation has been associated with psychiatric, neurological, and neurodegenerative diseases.
Multiple isoforms of GRIK1 exist and may undergo RNA editing within the second transmembrane domain, altering ion flow properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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