Thermo Fisher Scientific OX40L/TNFSF4 Recombinant Rabbit Monoclonal Antibody (BLR165J)
OX40L/TNFSF4 단백질을 인식하는 재조합 토끼 단클론 항체로, 인간 시료에 반응하며 Western blot에 적합합니다. HEK293F 발현 시스템에서 생산되었고 PBS 버퍼에 보존됩니다. 면역학 연구용으로 세포 간 상호작용 및 면역조절 신호 분석에 활용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR165J |
| Immunogen | Peptide representing a region between residue 1 and 50 of Human Tumor necrosis factor ligand superfamily member 4 (OX40L/CD252, UniProt ID: P23510-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 6.8–7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TNFSF4 (OX40L) is a type II membrane-bound, non-covalently linked homotrimeric protein expressed on antigen-presenting cells such as dendritic cells and activated B-cells, as well as vascular endothelial cells, mast cells, and natural killer cells.
It signals through the TNFRSF4 receptor, primarily expressed on CD4+ T cells and certain activated CD8+ T cells. The TNFRSF4/TNFSF4 interaction provides a costimulatory signal essential for productive communication between antigen-presenting cells and T cells, enhancing proliferation, survival, and expression of cytokines such as RANTES, IL-2, IL-3, and IFN-γ.
This signaling pathway plays a critical role in immunotolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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