Thermo Fisher Scientific NCOA2/SRC2 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and White-tufted-ear marmoset

Target Information

SRC2 (steroid receptor coactivator 2), also known as NCOA2 or TIF2, functions as a coactivator for nuclear hormone receptors. These receptors are conditional transcription factors that regulate gene expression related to cell growth, development, and homeostasis.
Members of the nuclear hormone receptor superfamily have three domains:

1. N-terminal transcriptional activation domain
2. Central DNA-binding domain
3. C-terminal hormone-binding domain

Before hormone binding, steroid receptors remain inactive in complexes with heat-shock protein-90 and other stress proteins. Hormone binding induces conformational changes that activate receptors, enabling DNA binding and transcriptional modulation. Coactivator proteins like SRC2 mediate transcription initiation after receptor binding.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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