Thermo Fisher Scientific Phospho-alpha Synuclein (Tyr125) Polyclonal Antibody
인간 알파-시뉴클레인 Tyr125 인산화 부위를 인식하는 토끼 폴리클로날 항체. Western blot 및 ICC/IF에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 파킨슨병 및 알츠하이머 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Suggested Positive Control: C2C12 cells
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:200
- Suggested Positive Control: HeLa cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y(p)-E-M) derived from Human alpha-Synuclein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554349 |
Product Specific Information
- Recommended positive control for WB: C2C12 cells
- Recommended positive control for ICC/IF: HeLa cells
Target Information
Alpha-synuclein is a member of the synuclein family, including beta- and gamma-synuclein. These proteins are abundant in the brain and regulate synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, indicating involvement in signaling pathways.
Mutations in the SNCA gene, encoding alpha-synuclein, are linked to Parkinson’s disease. Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Lewy Body Dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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