Thermo Fisher Scientific SETD2 Monoclonal Antibody (OTI1C4), TrueMAB
SETD2 단백질을 인식하는 Mouse monoclonal antibody로, Western blot에 최적화됨. Human 시료에 반응하며, Affinity chromatography로 정제된 1 mg/mL 액상 제품. PBS/BSA/glycerol buffer에 보관되며, -20°C에서 보존 권장. 연구용 전용 시약.
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1787–2144 of human SETD2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Histone methyltransferase that specifically trimethylates Lys-36 of histone H3 (H3K36me3) using dimethylated Lys-36 (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex. H3K36me3 also contributes to maintenance of heterochromatin by recruiting DNMT3A and is enhanced in intron-containing genes, linking splicing with elongating RNA polymerase. Required during angiogenesis and recruited to adenovirus 12 E1A gene promoters during infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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