Thermo Fisher Scientific PPP6C Recombinant Rabbit Monoclonal Antibody (6O2N8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6O2N8

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 206-305 of human PPP6C. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PPP6C,uniProtId:O00743-1,ncbiNodeId:9606,antigenRange:206-305,antigenLength:305,antigenImageFileName:MA5-55531_PPP6C_O00743-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55531_PPP6C_O00743-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.38 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: AISPRGAGWL FGAKVTNEFV HINNLKLICR AHQLVHEGYK FMFDEKLVTV WSAPNYCYRC GNIASIMVFK DVNTREPKLF RAVPDSERVI PPRTTTPYFL

Target Information

Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5to 3 exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5and 3 overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5and 3 overhang processing in nonhomologous DNA end joining.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.