Thermo Fisher Scientific PPP6C Recombinant Rabbit Monoclonal Antibody (6O2N8)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen Sequence:
AISPRGAGWL FGAKVTNEFV HINNLKLICR AHQLVHEGYK FMFDEKLVTV WSAPNYCYRC GNIASIMVFK DVNTREPKLF RAVPDSERVI PPRTTTPYFL

Target Information

Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that can cause double-strand DNA breaks. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, allowing the strands to rejoin.
Artemis is a single-strand-specific 5′ to 3′ exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, which then acquires endonucleolytic activity on 5′ and 3′ overhangs and hairpins. These activities are essential for V(D)J recombination and for 5′ and 3′ overhang processing in nonhomologous DNA end joining.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.