Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (R17217.1.4), Biotin
Biotin으로 표지된 마우스 Transferrin Receptor 단일클론 항체로 Flow Cytometry에 적합. Rat IgG2a 아이소타입, Protein G 정제. 철 흡수 관련 연구 및 세포 내 수용체 분석에 활용 가능. 연구용으로만 사용.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1.0 µg/1×10⁶ cells
- Publications: 1 (Miscellaneous PubMed)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | R17217.1.4 |
| Immunogen | Mouse CD71 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539304 |
Additional Formats
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome, and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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