Thermo Fisher Scientific TIE2 Polyclonal Antibody
TIE2(TEK) 수용체를 인식하는 Chicken Polyclonal 항체로, WB, IHC, ELISA, IP, Dot blot에 사용 가능. Affinity chromatography로 정제되었으며, 0.5–1.5 mg/mL 농도의 액상 제품. 내피세포 연구 및 혈관 발달 관련 신호전달 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Dot Blot (DB) | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 540–590 on human Tyrosine-protein kinase receptor Tie-1 isoform 2 protein (TIE2/TEK, UniProt ID: Q02763-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20 °C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling is critical for endothelial cell–smooth muscle cell communication during venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates signaling involved in embryonic vascular development. TIE2 expression is increased by thyroid-stimulating hormone and agents that elevate intracellular cAMP. Hematopoietic stem cells (HSCs) expressing TIE2 are quiescent and antiapoptotic, forming a side population adhering to osteoblasts in the bone marrow niche.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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