Thermo Fisher Scientific ATG16L1 Polyclonal Antibody
ATG16L1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 및 마우스 반응성 검증됨. IHC(P) 및 ICC/IF에 사용 가능. 고순도 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within AA 200–400 of human ATG16L1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792682 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (91%), Rat (93%), Pig (92%), Rhesus Monkey (80%), Bovine (94%).
- Positive Control: MEF.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Autophagy related protein 16L is encoded by the ATG16L gene and is located on chromosome 2 in humans. Also known as WD30 or IBD10 (Inflammatory Bowel Disease 10).
ATG12 and ATG5 conjugate and oligomerize with ATG16L to form an 800 kDa Atg16L complex, which facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE).
This ubiquitin-like conjugation system is a widely used marker for autophagy. The ATG16L complex, along with ATG18 and ATG21, prevents premature cleavage of ATG8-PE by the cysteine protease Atg4 until autophagosome completion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-85542_ATG16L1_Q676U5-1_Rabbit.svg, PA5-85542_ATG16L1_Q676U5-1_Rabbit_PDP.jpeg)
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