Thermo Fisher Scientific Connexin 46 Polyclonal Antibody
Connexin 46 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체로, 렌즈 세포 간 결합 연구에 적합.
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- PA564957
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Thermo Fisher Scientific Connexin 46 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Connexin 46. Recombinant protein control fragment (Product #RP-105732) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2665292 |
Product Specific Information
- Immunogen sequence: MEEKKKEREEE EQLKRESPSP KEPPQDNPSS RDDRGRVRMA G
- Highest antigen sequence identity to the following orthologs: mouse 56%, rat 56%.
Target Information
Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46, and C2P3, maps to human chromosome 13q11–q12 and encodes a 46 kDa protein.
Cx46, along with Cx50, is principally expressed in the lens of the eye. It mediates intercellular interactions during development and is necessary for the survival of neural crest cells.
Cx46 forms gap junctions that connect lens fiber cells and are crucial for maintaining lens transparency and normal lens function.
Mutations of Cx46 result in severe cataracts of the lens. Individual knockouts of Cx46 and Cx50 lead to changes in lens fiber cell differentiation and size, indicating their interaction is essential for proper fiber cell organization.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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