Thermo Fisher Scientific Npr2 Recombinant Rabbit Monoclonal Antibody (19C7)

Thermo Fisher Scientific Npr2 Recombinant Rabbit Monoclonal Antibody (19C7)

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:2,000
• Immunocytochemistry (ICC/IF): 1:50–1:200
• Flow Cytometry (Flow): 1:50–1:200
• ELISA: Assay-dependent

Product Specifications

Target Information

This gene encodes natriuretic peptide receptor B (NPR2), one of two integral membrane receptors for natriuretic peptides.
Both NPR1 and NPR2 contain five functional domains:

• Extracellular ligand-binding domain
• Single membrane-spanning region
• Intracellular protein kinase homology domain
• Helical hinge region involved in oligomerization
• Carboxyl-terminal guanylyl cyclase catalytic domain

NPR2 is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity.
Mutations in this gene cause acromesomelic dysplasia Maroteaux type.

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.