Thermo Fisher Scientific CD47 Polyclonal Antibody
CD47 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합. 합성 펩타이드(308–323aa)를 면역원으로 사용하며, 동결건조 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a sequence at the C-terminus of human CD47 (308–323aa, EPLNAFKESKGMMNDE) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2746103 |
Product Specific Information
- Synthetic peptide sequence: 308–323aa (EPLNAFKESKGMMNDE)
- Add 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
CD47 (integrin-associated protein, IAP) is a ubiquitously expressed transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 modulates signaling pathways including activation of heterotrimeric G proteins and intracellular calcium increase upon cell adhesion. It acts as a receptor for the C-terminal domain of thrombospondin and participates in membrane transport and signal transduction. CD47 interacts with CD172a (SIRP alpha) to inhibit phagocytosis, and influences cell migration, B cell adhesion, T cell activation, chondrocyte mechanotransduction, and neuronal development, especially in synapse-rich brain and retina regions.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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