Thermo Fisher Scientific ARPP21 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  ESSARPGGES LQDQESIHLQ LSSFSSLQEE DKSRKDDSER EKEKDKNKDK
• Storage recommendations:
  For short-term use, store at 2–8°C up to 1 week.
  For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology:
  Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Yeast: 82%

Target Information

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. ADCA types I–III are classified based on clinical and genetic features. ADCAI is genetically heterogeneous, with loci SCA1, 2, 3, 4, and 6 mapped to different chromosomes. ADCAII (SCA7) presents with retinal degeneration, while ADCAIII (SCA5) is considered a pure cerebellar syndrome. These disorders are caused by expansions of CAG repeats, resulting in elongated polyglutamine tracts in the corresponding proteins. The diseased allele typically contains 41–81 CAG repeats, compared to 6–39 in normal alleles, and is associated with spinocerebellar ataxia type 1 (SCA1). Two transcript variants encoding the same protein have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(해당 항체의 항원 구조 관련 이미지: PA5-113748_ARPP21_Q9UBL0-1_Rabbit.svg / PA5-113748_ARPP21_Q9UBL0-1_Rabbit_PDP.jpeg)