Thermo Fisher Scientific Phospho-SMC1 (Ser957) Polyclonal Antibody
Phospho-SMC1 (Ser957) 항체로, 인간 및 생쥐 시료에 반응합니다. IHC, ICC, Flow, ELISA 등 다양한 응용에 적합하며, 단백질 A 정제된 rabbit polyclonal antibody입니다. DNA 복구 및 염색체 응축 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human SMC1 around the phosphorylation site of Ser957 [GS(p-S)QG] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in nuclear events requiring structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair, and transcriptional repression.
SMC1 and SMC3 form a heterodimeric complex essential for metaphase progression and sister chromatid cohesion. Mutations in the SMC1 gene can lead to Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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