Thermo Fisher Scientific APE1 Recombinant Rabbit Monoclonal Antibody (ARC0556)
APE1 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체 ARC0556은 WB, IHC, ELISA에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 HEK293 세포에서 발현됩니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능합니다.
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Thermo Fisher Scientific APE1 Recombinant Rabbit Monoclonal Antibody (ARC0556)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0556 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human APEX1/APE1 (UniProt ID: P27695) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.26 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848992 |
Product Specific Information
Immunogen sequence:
MPKRGKKGAV AEDGDELRTE PEAKKSKTAA KKNDKEAAGE GPALYEDPPD QKTSPSGKPA TLKICSWNVD GLRAWIKKKG LDWVKEEAPD ILCLQETKCS
Target Information
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional enzyme involved in DNA repair and redox regulation of various proteins. APE1 repairs abasic sites in DNA and modulates transcription factors such as Fos, Jun, NF-κB, Myb, HIF-1α, CREB, and Pax. It also influences cell cycle control through p53 and plays roles in apoptosis.
APE1 expression varies by tissue and developmental stage, with regulation mediated by phosphorylation via casein kinase II. Elevated APE1 levels are observed in reoxygenated hypoxic cells and certain malignant tissues, while reduced expression is linked to apoptosis induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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