Thermo Fisher Scientific TCF7L2 Monoclonal Antibody (E.998.2)
TCF7L2 단백질을 인식하는 Rabbit monoclonal antibody로 Wnt signaling 연구에 적합. Western blot, IHC, IP, ChIP 등 다양한 응용 가능. Human 및 Mouse 반응성. 고순도 affinity chromatography로 정제된 액상 형태. -20°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 1 publication |
| Immunoprecipitation (IP) | 1:50 | - |
| ChIP assay (ChIP) | 1:50 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E.998.2 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Glu81 of human TCF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 28 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10979176 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TCF7L2, also known as TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. It regulates pro-glucagon gene expression, influencing glucose homeostasis and GLP-1 production. Genetic variants of TCF7L2 are associated with type 2 diabetes, affecting beta-cell survival and function. Multiple splicing isoforms are differentially expressed during cancer progression, and gene targeting studies show TCF7L2 is essential for maintaining small intestinal crypt stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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