Thermo Fisher Scientific HOXB4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Positive Samples: HL-60, Mouse liver
• Immunogen sequence:
  PEAGFGRRAA CTVQRYAACR DPGPPPPPPP PPPPPPPPGL SPRAPAPPPA GALLPEPGQR CEAVSSSPPP PPCAQNPLHP SPSHSACKEP VVYPWMRKVH V

Target Information

HOX homeobox genes play a role both in early stem cell function and in later stages of hematopoietic differentiation.
HOXB4 is a homeotic selector gene implicated in self-renewal of definitive hematopoietic stem cells (HSCs).
Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induces a switch to the definitive HSC phenotype.
Activation of WNT signaling in HSCs increases expression of HOXB4.
Perturbations of HOX gene expression can cause leukemia.

⚠ WARNING
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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