Thermo Fisher Scientific HOXB4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HOXB4 (NP_0769201) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HOXB4,uniProtId:P17483-1,ncbiNodeId:9606,antigenRange:50-150,antigenLength:251,antigenImageFileName:PA5-116699_HOXB4_P17483-1_Rabbit.svg,antigenImageFileNamePDP:PA5-116699_HOXB4_P17483-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.16 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2901330

Product Specific Information

Positive Samples: HL-60, Mouse liver

Immunogen sequence: PEAGFGRRAA CTVQRYAACR DPGPPPPPPP PPPPPPPPGL SPRAPAPPPA GALLPEPGQR CEAVSSSPPP PPCAQNPLHP SPSHSACKEP VVYPWMRKVH V

Target Information

HOX homeobox genes play a role both in the early stem cell function as well as in later stages of hematopoietic differentiation. HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive HSCs. Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induced a switch to the definitive HSC phenotype. Activation of WNT signaling in HSCs induced increased expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.