Thermo Fisher Scientific PDCD5 Polyclonal Antibody
Rabbit polyclonal antibody against human PDCD5 protein. Validated for IHC(P) and ICC/IF applications. Antigen affinity purified, unconjugated, supplied in liquid form. Suitable for apoptosis and tumor suppressor research.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PDCD5 (Product #RP-92017) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789786 |
Product Specific Information
Immunogen sequence:
MADEELEALR RQRLAELQAK HGDPGDAAQQ EAKHREAEMR NSILAQVLDQ SARARLSNLA LV
Target Information
Programmed cell death 5 (PDCD5) is a human apoptosis-related protein involved in early and universal stages of apoptosis. PDCD5 is widely expressed and upregulated during apoptosis, translocating from the cytoplasm to the nucleus. It has a compact core structure with mobile alpha-helices and an unstructured C-terminal region. Charged residues contribute to apoptosis promotion and cell translocation. PDCD5 enhances TAJ/TROY-induced cell death and acts as a Tip60 co-activator to promote apoptosis. Polymorphisms in the PDCD5 promoter region may influence susceptibility to certain cancers, including chronic myelogenous leukemia and lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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