Thermo Fisher Scientific DUOXA1 Polyclonal Antibody
Human DUOXA1 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제. PBS(40% glycerol, 0.02% sodium azide) 용액 형태로 제공. 4°C 단기, -20°C 장기 보관.
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DUOXA1. Recombinant protein control fragment (Product # RP-98473) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640823 |
Product Specific Information
Immunogen sequence:
VAHRMQPHRL KAFFNQSVDE DPMLEWSPEE GGLLSPRYRS MADSPKSQDI PLSEASS
Sequence identity:
- Mouse: 79%
- Rat: 79%
Target Information
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form heterodimers with maturation factors DUOXA1 and DUOXA2, which are essential for DUOX enzyme complex maturation and function.
The DUOXA1 gene encodes the DUOX1 activator or maturation factor. Rat studies identified a bidirectional promoter controlling both DUOX1 and DUOXA1 transcription. DUOXA1 is transported to the cell surface when coexpressed with DUOX1 and retained in the endoplasmic reticulum when expressed alone.
Expression of DUOX1 or DUOXA1 is not suppressed by thyroglobulin (Tg), whereas DUOX2 and DUOXA2 expression is significantly suppressed by Tg. DUOXA1 also functions as a p53-regulated neurogenic factor involved in p53-dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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