Thermo Fisher Scientific LRP12 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human LRP12. Recombinant protein control fragment (Product #RP-90323). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LRP12,uniProtId:Q9Y561-1,ncbiNodeId:9606,antigenRange:564-696,antigenLength:859,antigenImageFileName:PA5-53568_LRP12_Q9Y561-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53568_LRP12_Q9Y561-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643475

Product Specific Information

Immunogen sequence: FPVCSPNQAS VLENLRLAVR SQLGFTSVRL PMAGRSSNIW NRIFNFARSR HSGSLALVSA DGDEVVPSQS TSREPERNHT HRSLFSVESD DTDTENERRD MAGASGGVAA PLPQKVPPTT AVEATVGACA SSS

Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 89%.

Target Information

Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP12, also designated ST7, is a member of the LDLR family that is thought to be involved in the internalization of lipophilic molecules and/or signal transduction. LRP12 has been shown to interact with RACK1, MADHIP and Integrin beta-1-binding protein 3. It is widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. Overexpression of LRP12 may be associated with oral tumors, therefore implicating LRP12 as a potential oncogene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.