Thermo Fisher Scientific Phospho-SCNN1B (Thr615) Polyclonal Antibody
SCNN1B 단백질의 Thr615 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 Protein A 정제, 액상 형태로 안정적 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human SCNN1B around the phosphorylation site of Thr615 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of luminal sodium (and water) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and contributes to taste perception. Forms a heterotetramer of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit.
Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.
Defects in SCNN1B can cause:
- Pseudohypoaldosteronism type 1 (PHA1): a rare salt-wasting disease due to mineralocorticoid unresponsiveness.
- Liddle syndrome: autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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