Thermo Fisher Scientific PLA1A Polyclonal Antibody
PLA1A 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB와 IHC에 적합. Human 및 Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS 버퍼에 0.02% sodium azide 포함, 냉장 보관 권장. 연구용으로만 사용 가능.
- 카탈로그번호
- PA534460
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid synthetic peptide near the carboxy terminus of human PLA1A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551812 |
Product Specific Information
- Suggested positive control: human kidney tissue lysate
- PA5-34460 can be used with blocking peptide PEP-1502
Target Information
PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine.
This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets.
The resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators.
PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft.
It is also expressed in human THP-1-derived macrophages, with expression upregulated by lipopolysaccharide (a TLR4 ligand).
This upregulation is inhibited by corticosteroids, commonly used to suppress chronic allograft rejection.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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