Thermo Fisher Scientific PLA1A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Suggested positive control: human kidney tissue lysate
• PA5-34460 can be used with blocking peptide PEP-1502

Target Information

PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine.
This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets.
The resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators.

PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft.
It is also expressed in human THP-1-derived macrophages, with expression upregulated by lipopolysaccharide (a TLR4 ligand).
This upregulation is inhibited by corticosteroids, commonly used to suppress chronic allograft rejection.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.