Thermo Fisher Scientific Phospho-PKC beta-1 (Thr642) Recombinant Superclonal Antibody (24HCLC)
PKC beta-1 (Thr642) 인산화 부위를 인식하는 Rabbit recombinant Superclonal 항체. 높은 특이성과 재현성을 제공하며, 다양한 종(원숭이, 랫, 소, 마우스)에 반응 예측. Immunocytochemistry(ICC/IF)에 적합하며, 장기 보관 시 -20°C에서 안정적 유지.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 24HCLC |
| Immunogen | Peptide corresponding to Human PKC-beta (PKCB; PRKCB; PRKCB1; PRKCB2). Chemically synthesized phosphopeptide derived from a region of human PKCβI containing threonine 642. The sequence is conserved in rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2632980 |
Product Specific Information
- Predicted to react with Monkey, Rat, Bovine, and Mouse.
- Recombinant rabbit Superclonal™ antibodies are composed of multiple recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.
- Functionally similar to polyclonal antibodies, recognizing multiple epitope sites and providing high detection sensitivity for low-abundance targets.
- Each lot maintains consistent antibody populations by using defined recombinant heavy and light chain mixtures.
- Formerly referred to as “Recombinant Polyclonal Antibody”; now rebranded as “Recombinant Superclonal™ Antibody” with unchanged performance.
Target Information
The PKC (Protein Kinase C) family of serine/threonine kinases, including PRKCB1 (PKC beta I), is activated by intracellular signal transduction pathways.
At least 12 PKC isoforms have been identified in humans, differing in structure, distribution, localization, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family, which is Ca²⁺- and phospholipid-dependent.
PKC family members phosphorylate various protein targets, participating in diverse signaling pathways and serving as receptors for phorbol esters (tumor promoters).
PKC beta I is implicated in B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Mouse studies suggest roles in neuronal regulation and stress-related behavior.
Alternative splicing results in distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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